Expression of fibromodulin in carotid atherosclerotic plaques is associated with diabetes and cerebrovascular events
نویسندگان
چکیده
منابع مشابه
Expression of fibromodulin in carotid atherosclerotic plaques is associated with diabetes and cerebrovascular events.
AIMS The small leucine-rich proteoglycans fibromodulin and lumican are functionally related extracellular matrix proteins involved in the regulation of collagen fiber formation. Fibromodulin-deficient apolipoprotein E-null mice have decreased vascular retention of lipids and reduced development of atherosclerosis suggesting that fibromodulin may influence the disease process. The aim of the pre...
متن کاملLow TLR7 gene expression in atherosclerotic plaques is associated with major adverse cardio- and cerebrovascular events
AIMS Processes in the development of atherosclerotic lesions can lead to plaque rupture or erosion, which can in turn elicit myocardial infarction or ischaemic stroke. The aims of this study were to determine whether Toll-like receptor 7 (TLR7) gene expression levels influence patient outcome and to explore the mechanisms linked to TLR7 expression in atherosclerosis. METHODS AND RESULTS Ather...
متن کاملABCA1 expression in carotid atherosclerotic plaques.
BACKGROUND AND PURPOSE The ATP-binding cassette transporter A1 (ABCA1) facilitates cholesterol efflux from cells, a key process in reverse cholesterol transport. Whereas previous investigations focused on mutations causing impaired ABCA1 function, we assessed the role of ABCA1 in human carotid atherosclerotic disease. METHODS We compared the mRNA and protein levels of ABCA1, and one of its ke...
متن کاملATG16L1 Expression in Carotid Atherosclerotic Plaques Is Associated With Plaque Vulnerability.
OBJECTIVE Autophagy has emerged as a cell survival mechanism critical for cellular homeostasis, which may play a protective role in atherosclerosis. ATG16L1, a protein essential for early stages of autophagy, has been implicated in the pathogenesis of Crohn's disease. However, it is unknown whether ATG16L1 is involved in atherosclerosis. Our aim was to analyze ATG16L1 expression in carotid athe...
متن کاملIncreased expression of bFGF is associated with carotid atherosclerotic plaques instability engaging the NF-κB pathway
Unstable atherosclerotic plaques of the carotid arteries are at great risk for the development of ischemic cerebrovascular events. The degradation of the extracellular matrix by matrix metalloproteinases (MMPs) and NO-induced apoptosis of vascular smooth muscle cells (VSMCs) contribute to the vulnerability of the atherosclerotic plaques. Basic fibroblast growth factor (bFGF) through its mitogen...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Atherosclerosis
سال: 2015
ISSN: 0021-9150
DOI: 10.1016/j.atherosclerosis.2015.06.023